Special dosage forms often alter the characteristics or phase of the original drug, or combine the original drug with a carrier with a special structure, resulting in significant changes in the physicochemical properties of the formulation. This will greatly affect the in vivo processes of the drug, exhibiting different pharmacokinetic characteristics from the original drug in various aspects such as absorption, distribution, metabolism, and excretion. Relying on the "State Key Laboratory of Drug Release Technology and Pharmacokinetics", Tiancheng has been deeply engaged in the evaluation of high-end preparations for more than 17 years, completed a number of preclinical research projects for highly difficult preparations such as microspheres, liposomes, micelles, and oral solubilized membranes, and has profound technology and rich experience in the evaluation of slow and controlled release preparations, nano preparations, inhalation preparations, and other fields.

Technical Research and Development

• Research on Enhancing Drug Directed In vivo Processes with Nanodrug Carriers (National 973 Project)
• Research on Key Technologies and Applications of New Carrier Drug Delivery System and Its Comprehensive Evaluation of Drug Properties (National Science and Technology Support Program Project)
• Mechanism Study on Enhancing the Activity and Efficacy of Anti tumor Drugs with Nanomicelles (Key Project of National Natural Science Foundation of China)
• Key Technologies for Targeted Drug Delivery and Industrialization Research of New Products (National Science and Technology Major Project)
• Drug Evaluation Technology for Nano Carrier Drugs (Tianjin Science and Technology Plan)
• Research on Major Common Key Technologies of New Inhalation Drug Delivery Formulations and Their Large Scale Development - Non Clinical Pharmacology and Toxicological Evaluation Technology Research (National Science and Technology Major Project)

Technical Application

Evaluation of nanocarrier drugs
Tiancheng specializes in preclinical evaluation of various nano formulations and has completed multiple research projects on nano carrier drugs. Among them, in cooperation with the National Center for Nanoscience, it helped the first therapeutic new drug named "nano" in China obtain implied clinical trial approval.

Inhalation formulation evaluation
Tiancheng is equipped with a number of large and small animal inhalation delivery systems, and has established a mature evaluation system for inhalation preparations, which can provide research services for oral and nasal exposure toxicity, pharmacodynamics and pharmacokinetics of rodents (rats, guinea pigs) and non rodents (beagles). The evaluable dosage forms include inhalation aerosols, inhalation aerosols and aerosol inhalation liquid preparations. Many completed projects have entered the clinical trial stage.