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Pharmacokinetics
Pharmacokinetics

Tiancheng's pharmacokinetic research system originated from the Pharmacokinetic Laboratory established by Academician Liu Changxiao in 1968. It is the oldest professional institution for pharmacokinetic research in China, gathering the wisdom and experience of several generations of researchers. During the "Ninth Five Year Plan" to "13th Five Year Plan" period, it successfully completed multiple national level major scientific and technological projects and was able to undertake preclinical in vitro/in vivo pharmacokinetic research that meets the requirements of new drug registration Clinical pharmacokinetic research has completed hundreds of new drug development projects. Relying on the "State Key Laboratory of Drug Release Technology and Pharmacokinetics", we have continued to invest in basic research of pharmacokinetics, focused on technology exploration, kept up with the international frontier, and took a leading position in the research fields of innovative dosage forms, pharmacokinetics, drug transporters, etc.

In vitro pharmacokinetic studies

Pharmacokinetic studies based on transporters

Pharmacokinetic studies based on enzyme kinetics

Metabolic stability and pathways

Permeability evaluation of Caco-2, PAMPA, and MDCK

Research on preclinical DMPK on animal models

Overall scheme design and method development

Various genera and routes of administration

Study on drug absorption and bioavailability

Study on drug plasma protein binding

Research on drug tissue distribution

Metabolites and metabolic pathways in vivo

Excretion studies, material balance analysis

PK parameter calculation and analysis

PK/PD/TOX correlation analysis

Clinical pharmacokinetics

Study on human plasma exposure spectrum

Study on Human Plasma Dynamics

Human Excretion and Material Balance

Human metabolic products and metabolic pathways

Research on Human Drug Drug Interaction

Pharmacokinetic studies on special populations

MIST evaluation

Pharmacokinetics of radioisotope labeled compounds

Plasma dynamics, distribution, material balance

Analysis of plasma exposure and metabolic pathways

Research on improved new drug DMPK

Scheme design and method development

In vivo/in vitro exposure mass spectrometry study

Identification of target components

Precursor, salt modifying drugs, optical isomers

Special dosage forms

Consistency evaluation of generic drugs

BCS Classification Permeability Evaluation

BE Research Plan Design

Development and validation of analytical methods

Clinical trial sample testing

Data processing and statistical analysis

CTD report writing

Tianjin Tiancheng Drug Assessment Research Co.,Ltd.

Address:No.308,Huiren Avenue,Binhai Science and Technology Park,Binhai High-Tech Industrial Development Area,Tianjin

Tel:022-84845325

E-mail:BD@tipr.com.cn

Wechat:tjtccro

Tianjin Tiancheng Drug Assessment Research Co.,Ltd.

Address:No.308,Huiren Avenue,Binhai Science and Technology Park,Binhai High-Tech Industrial Development Area,Tianjin

Tel:022-84845325

E-mail:BD@tipr.com.cn

Wechat:tjtccro

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