How are drugs absorbed, distributed, and excreted in the human body? Drug transporters are tiny 'movers' who assist in this process. Drug transporters are a series of proteins that exist on the surface of biological cell membranes and are widely distributed in various organs of the human body. They act as active transporters inside and outside the cell membrane, completing the process of drug transport from extracellular to intracellular or from intracellular to extracellular, playing a crucial role in the entire process of drug delivery within the body.
Tiancheng's drug transporter research platform was established in 2010 and is the earliest professional platform in China to apply drug transporter research to new drug development. At present, a drug evaluation system for intestinal absorption, blood brain barrier crossing, liver intake, bile excretion, kidney excretion of simulated drugs has been established, as well as multiple new drug research and development technology platforms for tumor resistance research, tumor specific target screening, hyperuricemia and diabetes drug screening, basically covering the research content recommended by the FDA and EMA guidelines, and has carried out project cooperation with many domestic scientific research institutions. In recent years, it has helped more than 10 well-known pharmaceutical enterprises to complete more than 40 new drug research and development projects.